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From First Principles
30 episodes
What Claude Actually Did to the Riemann Hypothesis (EP 53)
Ep 53 · Aug 14, 2026 · 1 hr 47 min
Claude did not solve the Riemann Hypothesis. But what it actually did may be one of the clearest examples yet of how rapidly AI systems are changing the way difficult mathematics can be attacked. In Episode 53, Lester Nare and Krishna Choudhary go from first principles on arguably the most famous unsolved problem in mathematics. We begin with Euler and the Basel problem, build the Riemann zeta function from the ground up, explain its deep connection to prime numbers, move into the complex plane…
The Amazon’s Hidden Civilization (One Year Anniversary) (EP 52)
Ep 52 · Aug 6, 2026 · 1 hr 47 min
In this anniversary episode, Lester Nare and Krishna Choudhary look back at how two longtime friends turned their regular conversations about science into a show now shared by millions of people around the world, and what they hope to build with FFP Nation in Year Two. Then we turn to a new Nature paper challenging the idea that the precolonial Amazon was sparsely populated. Airborne LiDAR revealed hundreds of geometric earthworks hidden beneath the rainforest canopy. Combining the new survey wi…
The Tech Elon Has Been Waiting For (EP 51)
Ep 51 · Jul 31, 2026 · 1 hr 44 min
What happens when electronics can operate at temperatures hot enough to melt aluminum? In this deep-dive episode, Lester Nare and Krishna Choudhary examine a new high-temperature memory device developed by researchers at USC, the Air Force Research Laboratory, Kumamoto University, and their collaborators. Published in Science, the experimental memristor combines tungsten, hafnium oxide, and graphene. It operated reliably at 700°C—roughly 1,300°F—retained data for more than 50 hours, and survived…
AI Breaks a 90-Year Math Problem, Life’s Alphabet in Space, and Science Funding (EP 50)
Ep 50 · Jul 23, 2026 · 1 hr 53 min
Hosted by Lester Nare and Krishna Choudhary, this episode moves from astrobiology to science policy to the rapidly changing frontier of artificial intelligence and mathematics. First, researchers analyzing pristine samples returned from asteroid Ryugu report all five canonical nucleobases used by DNA and RNA. We explain what that does—and does not—mean for the origin of life, how JAXA’s Hayabusa2 mission collected uncontaminated asteroid material, and why comparisons with NASA’s Bennu samples st…
FIFA Data Scientists Explain Match Momentum (EP 49)
Ep 49 · Jul 17, 2026 · 40 min
In this special interview episode, Lester Nare speaks with Juan Busso, Senior Football Data Scientist at FIFA, and Arron Ackerman, FIFA’s Team Lead for Football Performance Analysis, about the data science behind the Match Momentum visualization featured throughout the 2026 World Cup. What does “momentum” actually mean in football—and how can it be measured without reducing the game to possession or shots? Juan and Arron explain how FIFA translates football principles into mathematical models, v…
Black Hole Movies, Digital Heart Twins, and World Cup Tech (EP 48)
Ep 48 · Jul 14, 2026 · 1 hr 48 min
Hosted by Lester Nare and Krishna Choudhary, this episode returns to the FFP science rundown with stories spanning astrophysics, precision medicine, medical imaging, artificial intelligence, and World Cup technology. We begin with the Event Horizon Telescope and its evolving view of M87*, the supermassive black hole 55 million light-years away. How do you image something that appears about as small as a donut on the Moon? Krishna explains angular resolution, the Rayleigh limit, radio interferome…
America 250: The Breakthroughs That Built American Science — Part 2 (EP 47)
Ep 47 · Jul 3, 2026 · 2 hr 21 min
Hosted by Lester Nare and Krishna Choudhary, this episode is part two of our July 4th America 250 special: a celebration of the scientific, technological, institutional, and cultural breakthroughs that helped shape the United States into one of the most important scientific nations in human history. In part one, we traced American science from Benjamin Franklin and the founding documents through Sputnik, NASA, DARPA, Bell Labs, the transistor, information theory, nuclear physics, molecular biolo…
America 250: The Breakthroughs That Built American Science — Part 1 (EP 46)
Ep 46 · Jul 2, 2026 · 1 hr 50 min
Hosted by Lester Nare and Krishna Choudhary, this episode is part one of our July 4th America 250 special: a celebration of the scientific, technological, institutional, and cultural innovations that helped shape the United States into one of the most important scientific nations in human history. For America’s 250th anniversary, we built an interactive timeline of the discoveries, inventions, institutions, and funding systems that enabled American science to grow from Benjamin Franklin’s experi…
The Physics of the World Cup: VAR, Smart Balls, and Soccer Aerodynamics (EP 45)
Jun 29, 2026 · 60 min
Hosted by Lester Nare and Krishna Choudhary, this episode is our World Cup special — a deep dive into the science, physics, engineering, and data behind the beautiful game. We start with the offside rule and the controversy around semi-automated VAR. How can a system decide whether a player is onside or offside by only a few inches? Krishna breaks the problem down like an experimental physicist: player speed, ball-contact time, camera frame rate, significant digits, and the error budget behind t…
New Rules For Heredity (Non-Mendelian Inheritance of Epigenetics) (EP 44)
Ep 44 · Jun 26, 2026 · 1 hr 38 min
Hosted by Lester Nare and Krishna Choudhary, this episode marks Krishna’s return to the studio after paternity leave — and the timing could not be more fitting. Today’s deep dive is about inheritance: not just the classic Mendelian rules most of us learned in biology class, but the stranger, more dynamic world of non-Mendelian epigenetic inheritance. Starting from Gregor Mendel and his pea plants, Lester and Krishna rebuild the foundations of genetics from first principles: dominant and recessiv…
Dr. Michael Blanton on Open Data, Galaxy Surveys, and the Future of Astronomy (EP 43)
Ep 43 · Jun 4, 2026 · 43 min
Hosted by Lester Nare and Krishna Choudhary, this episode is the second interview in our ongoing collaboration series with Carnegie Observatories. Krishna sits down with Dr. Michael Blanton, the new Director of the Carnegie Observatories, for a wide-ranging conversation on how astronomy became one of the most data-rich sciences, how the Sloan Digital Sky Survey helped change the culture around open data, what the next era of astronomical data science and AI could look like, and one of the galaxy…
How Scientists Actually Study Dark Matter (EP 42)
Ep 42 · May 21, 2026 · 1 hr 7 min
Hosted by Lester Nare, this episode features astrophysicist Dan Gilman for a deep conversation on one of the biggest open questions in modern physics: what dark matter actually is. Starting from first principles, Lester and Dan walk through why the evidence for dark matter is now so strong, how strong gravitational lensing works, why tiny distortions in lensed light can reveal invisible clumps of matter, and how the next generation of surveys may transform the field. Krishna is out on family lea…
Dr. John Mulchaey on Carnegie Science and the Future of Astronomy (EP 41)
Ep 41 · May 13, 2026 · 37 min
Hosted by Lester Nare and Krishna Choudhary, this interview features John Mulchaey, the 12th President of Carnegie Science and former Director of the Carnegie Observatories. The conversation starts with his early work on galaxy groups and dark matter, then expands into how Carnegie works as a scientific institution, what the Giant Magellan Telescope could unlock for exoplanets and astronomy, how science funding actually works, and why eclipse chasing is still one of the most magical experiences…
Ant Scans, Lunar Chickpeas, Hidden Galaxies & Superconductivity (EP 40)
Ep 40 · Apr 29, 2026 · 37 min
Hosted by Lester Nare and Krishna Choudhary, this rundown episode covers four new science stories at a high level: a huge new 3D ant imaging database built with synchrotron X-ray microtomography, a lunar agriculture experiment that grew chickpeas in simulated moon soil using fungi and worm waste, AI-assisted discovery of strange objects in the Hubble archive, and a new programmatic roadmap for room-temperature superconductivity. There is also another round of Are You Smarter Than a Scientist? in…
The Prometheus Constellation: Dramaturgical and Scientific Analysis of the Physicists in Oppenheimer (EP 39)
Ep 39 · Apr 21, 2026 · 1 hr 37 min
Hosted by Lester Nare and Krishna Choudhary, this special episode ranks the 26 scientists shown in Christopher Nolan’s Oppenheimer by one standard only: their contribution to fundamental science. Starting with the Manhattan Project figures near the bottom and working up through the giants of quantum mechanics, relativity, nuclear physics, and logic, the episode turns a movie cast list into a surprisingly deep walk through the history of modern physics. Summary A ranking framework that actually m…
Harder Than Diamond? The New Hexagonal Diamond Breakthrough (EP 38)
Ep 38 · Apr 15, 2026 · 58 min
Hosted by Lester Nare and Krishna Choudhary, this episode is a deep dive into one of the strangest and most hard-fought materials science stories in decades: the claim that researchers have finally synthesized bulk hexagonal diamond, also known as lonsdaleite. They break down why this material matters, how it differs from ordinary cubic diamond, why scientists argued about its existence for more than 50 years, and what the new Nature paper actually did to convince skeptical reviewers. Summary Wh…
Artemis II: Deep Dive on the Moon Flyby, Earthset, and Reentry (EP 37)
Ep 37 · Apr 9, 2026 · 1 hr 26 min
Hosted by Lester Nare and Krishna Choudhary, this episode is a full deep dive on Artemis II as the crew returns from humanity’s first crewed lunar flyby in more than 50 years. Lester and Krishna break down the mission photo by photo, from launch and translunar injection to Earthset, Earthrise, the in-space solar eclipse, the science of lunar observations, and the skip-entry reentry profile bringing Orion home. Summary Why Artemis II is historic, what the crew saw on the far side of the Moon, and…
Artemis II, Claude Code Leak, iPhone Spyware & Project Hail Mary (EP 36)
Ep 36 · Apr 3, 2026 · 1 hr 1 min
Hosted by Lester Nare and Krishna Choudhary, this rundown episode covers five new science and tech stories at a high level: NASA’s Artemis 2 moon mission, what actually leaked in the Claude Code incident, a new cancer genomics paper suggesting domesticated cats may be unusually useful real-world models for human cancer, two leaked iPhone spyware toolkits, and a science-focused review of Project Hail Mary. Summary Artemis 2 is finally flying — why this mission matters, why it is not landing yet,…
Can AI Help Wake Coma Patients? The Science of Consciousness (EP 35)
Ep 35 · Mar 31, 2026 · 1 hr 9 min
Hosted by Lester Nare and Krishna Choudhary, this episode is a deep dive into one of the hardest questions in neuroscience: what breaks in the brain during a coma, and can we figure out how to turn consciousness back on? We unpack a new paper from Daniel Toker et al. that uses an interpretable AI framework — not a generic black box chatbot model — to reverse engineer the biological mechanisms of prolonged unconsciousness, recover known features of coma, predict new ones, and propose a possible n…
AI Cancer Vaccines, Strange Fish, Ketamine, and Ancient Life (EP. 34)
Ep 34 · Mar 27, 2026 · 45 min
Hosted by Lester Nare and Krishna Choudhary, this episode is a fast-moving science rundown covering four remarkable stories from across AI, genetics, neuroscience, and paleontology. We dig into the story of a machine learning engineer who used AI tools to help design a personalized cancer vaccine for his dog, explore how an all-female fish species has survived far longer than evolutionary theory would predict, unpack new brain-scan evidence for how ketamine may rapidly relieve severe depression,…
Can Human Neurons Really Play Doom? The Science Behind Wetware (EP. 33)
Ep 33 · Mar 24, 2026 · 1 hr 13 min
Hosted by Lester Nare and Krishna Choudhary, this episode is a deep dive into one of the strangest science stories of the year: a dish of human neurons allegedly learning to play Doom. We go back to the original 2022 DishBrain paper out of Cortical Labs, unpack how biological neurons can be read and written with multi-electrode arrays, and then compare the peer-reviewed Pong result to the much newer Doom claim. The result is a story that is both genuinely impressive and, in places, probably over…
5,000-Year-Old Bacteria, Solar Storms, Dogs, and Meta’s AI War (EP. 32)
Ep 32 · Mar 20, 2026 · 39 min
Hosted by Lester Nare and Krishna Choudhary, this is our first standalone rundown episode — a faster, looser format where we hit several stories we didn’t have room to turn into full deep dives. This week: bacteria revived from a Romanian ice cave after 5,000 years, a speculative but fascinating theory linking solar storms to earthquakes, new evidence that dogs and humans share genetic roots for personality traits, and the increasingly dramatic fight over the future of AI after Yann LeCun leaves…
Optovolution: Teaching Proteins to Think Like Computers (EP. 31)
Ep 31 · Mar 18, 2026 · 56 min
Hosted by Lester Nare and Krishna Choudhary, this episode is a deep dive into a new synthetic-biology breakthrough out of EPFL: OptoEvolution. The big idea is simple but powerful — traditional directed evolution is great at making proteins that are always “on,” but biology is full of proteins that need to switch states, respond to stimuli, and behave more like logic gates than static tools. This paper takes directed evolution and couples it to light and the cell cycle, creating a new way to evol…
Can We Stop an Asteroid? The Physics Behind NASA’s DART Mission (EP. 30)
Ep 30 · Mar 16, 2026 · 54 min
Hosted by Lester Nare and Krishna Choudhary, this episode is a full deep dive on planetary defense. We break down NASA’s DART mission, why the goal was never to “blow up” an asteroid but to gently nudge it, and why the newest result is even bigger than the original headline: scientists can now directly detect that the Didymos–Dimorphos system changed not just locally, but in its heliocentric path around the Sun. Summary DART actually worked — not just by shortening Dimorphos’s local orbit around…
Astrobiology’s Biggest Survival Test + A Vaccine Against Everything? (EP. 29)
Ep 29 · Mar 12, 2026 · 2 hr 4 min
Hosted by Lester Nare and Krishna Choudhary, this episode starts in astrobiology with a fresh experimental challenge to one of the biggest objections to lithopanspermia: can life actually survive the violence of being blasted off a planet by an asteroid impact? Then, after a packed Rundown, we pivot hard into immunology with a radical Stanford paper asking whether we could build one nasal vaccine that doesn’t target a specific pathogen at all—but instead makes the lung itself a stronger fortress…
Dark Galaxies, Fuzzy Dark Matter, and an Alzheimer’s Breakthrough (EP. 28)
Ep 28 · Mar 4, 2026 · 1 hr 52 min
Hosted by Lester Nare and Krishna Choudhary, this episode has two main stories: an astrophysics update on a candidate “dark galaxy” in the Perseus Cluster (a halo that’s ~99.9% dark matter), and a major Alzheimer’s mechanism paper tracing how exercise protects the brain by repairing the blood–brain barrier—with an actionable drug-like path already emerging. Summary Candidate dark galaxy — Hubble + Euclid stacking and globular clusters reveal an ultra-faint halo that could test missing satellites…
Dream Engineering, the Proton Radius Puzzle, and an ALS Breakthrough (EP. 27)
Ep 15 · Feb 26, 2026 · 2 hr 12 min
Hosted by Lester Nare and Krishna Choudhary, this episode has three main stories: interactive dream engineering (yes, two-way “communication” during lucid dreaming), the proton radius puzzle finally getting resolved by a precision lab measurement, and a sobering but hopeful look at ALS—including a breakthrough “ALS-in-a-dish” model that could finally make drug screening translate to humans. Summary Dream engineering — targeted cues + induced lucidity → dream-content biasing and measurable next-d…
Winter Olympics Deep Dive: Ice Physics, Performance Pressure, and Climate Change (EP. 26)
Ep 26 · Feb 18, 2026 · 1 hr 50 min
Hosted by Lester Nare and Krishna Choudhary, this episode is a Winter Olympics deep dive from first principles—physics, neuroscience, and climate science in one ride. • Why ice is slippery: the “water layer” story is incomplete—new nanoscale measurements suggest a far more viscous, thicker interfacial film than textbook intuition. • Choking under pressure: how high stakes can disrupt neural control—reward signals can push brain states out of the “optimal zone.” • Climate change vs winter sports:…
Plants, Quantum Sensors, and Predicting Cancer Evolution (EP. 25)
Ep 25 · Feb 10, 2026 · 1 hr 49 min
Hosted by Lester Nare and Krishna Choudhary, this episode jumps from plant biochemistry to quantum metrology to cancer evolution. We start with a University of York breakthrough that solves a ~50-year mystery in alkaloid biosynthesis—identifying the “missing” enzyme behind a key asymmetric step plants use to build powerful defensive (and pharmaceutically useful) molecules. Then we go deep on quantum sensing with entangled atomic clouds, showing how correlated measurements can beat the standard q…
Artemis II, Apollo, and the Physics of Going Back to the Moon (EP. 24)
Ep 24 · Feb 4, 2026 · 1 hr 10 min
Hosted by Lester Nare and Krishna Choudhary, this episode is a full-spectrum moonshot: why Artemis II matters, how the mission actually works (SLS, Orion, translunar injection, free-return trajectories), and a first-principles teardown of the most common Apollo “hoax” claims—Van Allen belts, waving flags, shadows, and “why aren’t there stars?” We also run a quick Rundown of wild science headlines (ancient cave art, elevation-dependent warming, dogs and vocabulary, and peptide bonds in deep space…
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