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Every episode
Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas
30 episodes
364 | Stuart Firestein on How Science Relies on Ignorance and Failure
Ep 364 · Aug 17, 2026 · 1 hr 16 min
One of the paradoxes of science is that it seeks objectively true understanding of the world, but its methodology is driven by ignorance, failure, and uncertainty. Some phenomena we understand pretty well, but interesting research happens at the boundary of what we do and don't know. And there is no foolproof algorithm for moving in the right direction; we need to make conjectures and test them against the world. Biologist Stuart Firestein has been advocating for a better public understanding of…
363 | Chandra Sripada on How LLMs and Humans are Cognitive Cousins
Ep 363 · Aug 10, 2026 · 1 hr 52 min
Large Language Models display an uncanny ability to construct human-sounding speech, and can synthesize concepts in novel ways. Is this because they are truly thinking like human beings in some way, or have they found a way to be human-like without reproducing the internal mechanisms of human thought? Chandra Sripada argues that LLM cognition is more human-like than we suppose, and offers evidence from the ways that cognitive scientists study actual humans. Blog post with transcript: https://pre…
Mindscape Ask Me Anything, Sean Carroll | August 2026
Aug 3, 2026 · 3 hr 58 min
Welcome to the August 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy! Blog post with questions and full transcript:…
362 | Luis Bettencourt on the Universal Properties of Self-Organizing Cities
Ep 362 · Jul 27, 2026 · 1 hr 20 min
People who live in large cities produce more patents per person than those who live in small towns. They also walk faster down the street, and use less infrastructure per person. Indeed, the relationships between these quantities and city population obey power laws with apparently universal exponents, reminiscent of scaling laws is biological organisms? Luis Bettencourt argues that they can be explained in similar ways, using ideas from complex systems and network theory. Blog post with transcri…
361 | Bonnie Bassler on How Bacteria Talk and Work Together
Ep 361 · Jul 20, 2026 · 1 hr 16 min
One of the characteristics of life is that living organisms gather information and put it to use. Even one of the simplest lifeforms, bacteria, are able to sense features of their surroundings and alter their behavior accordingly. Most impressively, they are able to sense the presence of similar bacteria by a process called quorum sensing. Today's guest, Bonnie Bassler, is a leader in this field, and explains how quorum sensing allows groups of bacteria to do things (including in our bodies) tha…
Mindscape Ask Me Anything, Sean Carroll | July 2026
Jul 13, 2026 · 4 hr 3 min
Welcome to the July 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy! Blog post with transcript: https://preposterousu…
360 | Marc Berman on the Science of Touching Grass
Ep 360 · Jul 6, 2026 · 1 hr 30 min
Modern life has, in many ways, removed us from the environments in which our ancestors lived and adapted. Not only do we spend time looking at screens, but we spend time indoors, or outdoors but in urban spaces. How does this affect how we think and feel? Psychologist Marc Berman is a pioneer of "environmental neuroscience." In his recent book, Nature and the Mind: The Science of How Nature Improves Cognitive, Physical, and Social Well-Being, he presents evidence that spending time in nature not…
359 | Solo: Theories of Dark Energy
Ep 359 · Jun 29, 2026 · 1 hr 56 min
The cosmological constant, as discussed last episode, provides a perfectly good (thus far) explanation for why we observe the universe to be accelerating. But it might not be the right explanation, and demonstrating that would be yet another foundational discovery. In this episode I discuss what is required to invent a plausible theory of dynamical dark energy, This includes considerations from particle physics, possible experimental tests, and the option that we should modify gravity rather tha…
358 | Solo: Vacuum Energy and the Cosmological Constant
Ep 358 · Jun 22, 2026 · 1 hr 60 min
The most surprising discovery in fundamental physics during my career as a scientist was undoubtedly the acceleration of the universe, announced in 1998. The most straightforward explanation for these observations is a positive cosmological constant, or vacuum energy. I talk about the origin of the idea with Einstein, how quantum physicists started to think about it and understand the "cosmological constant problem," as well as how its discovery also raised the "coincidence problem." This is the…
357 | Jeff Coller on mRNA, Vaccines, and Bespoke Therapeutics
Ep 357 · Jun 15, 2026 · 1 hr 20 min
Messenger RNA (mRNA) plays a literally central role in the functioning of life as we know it, shuttling information back and forth between the DNA where it is stored to the ribosome where it is used to produce proteins. RNA may even have been the first molecule to kick-start the origin of life. Today, scientists are learning how to manipulate mRNA to cure and prevent diseases, whether through vaccination or literally editing one's DNA. Jeff Coller explains how it all works and how mRNA is revolu…
356 | Andrea Wulf on Enlightenment, Nature, Romanticism, and Modernity
Ep 356 · Jun 8, 2026 · 1 hr 17 min
All ideas have a history, no matter how inevitable and well-entrenched they may seem to us today. The later Enlightenment was a heady time when people were exploring new conceptions of nature, humanity, and the self. Andrea Wulf is a writer of narrative histories, examining the origins of ideas through the lives of the people who explored them. In this episode we discuss three of her books: The Invention of Nature, about Alexander von Humboldt and environmentalism; Magnificent Rebels, about the…
AMA | June 2026
Jun 1, 2026 · 3 hr 57 min
Welcome to the June 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy! Blog post with AMA questions and transcript: htt…
355 | Solo: Looking Quantum Mechanics in the Eyeball
Ep 355 · May 24, 2026 · 1 hr 44 min
One of the major obstacles to understanding quantum mechanics is the difficulty we have in simply accepting what the theory itself is telling us. The problem is that we know what the everyday world looks like -- stuff, arranged in space, evolving through time. So we can't resist the temptation to impose that picture on the quantum description, even if it's not actually there. In this solo episode I talk about what it means to take quantum mechanics at face value, and the difficult work involved…
354 | Christian List on Free Will and Levels of Reality
Ep 354 · May 18, 2026 · 1 hr 27 min
Did I have any freedom in choosing this particular podcast guest? At the level of particles, fields, and the fundamental laws of physics; no. At the level of human agents navigating the world, yes. Today's guest, Christian List, is a philosopher and political scientist who has arguably done the most to articulate the "compatibilist" perspective on free will, according to which the freedom of rational agents is entirely compatible with underlying mechanistic laws. The reconciliation depends on th…
353 | Alvin Roth on the Economics of Morally Contested Markets
Ep 353 · May 11, 2026 · 1 hr 12 min
Economic markets are efficient ways of deciding fair prices, at least in ideal circumstances of perfect competition, information, and choice. But there is more to life than fair prices. Two people might decide on a fair price to carry out a contract killing, but society generally frowns on the idea. Many examples of morally contestable markets feature less consensus than that one: sex work, drugs, selling organs, adopting children. In his new book Moral Economics, economist Alvin Roth investigat…
AMA | May 2026
May 4, 2026 · 4 hr 6 min
Welcome to the May 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy! Blog post with AMA questions and full transcript:…
352 | Bing Brunton on Connecting the Connectome to the Body
Ep 352 · Apr 27, 2026 · 1 hr 14 min
The connectome is the wiring diagram of a brain, a big matrix that tells us what neurons talk to what other neurons. Understanding it is an important step to understanding how brains work, but a long way from the final answer. A big next step is understanding how neuronal circuits connect to and guide bodily behavior. Very recent work on mapping the fruit-fly connectome has brought us closer to that goal. I talk with neuroscientist Bing Brunton about the connectome, how we can study it to unders…
351 | Peter Singer on Maximizing Good for All Sentient Creatures
Ep 351 · Apr 20, 2026 · 1 hr 16 min
Peter Singer has been an influential philosopher for a number of decades. He was a significant early voice in animal rights, has been a leading thinker of utilitarianism, and helped inspire the effective altruism movement. In this podcast episode, we try our best to talk about all of those things -- working from metaethical questions of consequentialism vs. other approaches, to specific flavors of utilitarianism, the practical demands that ethics places on people, the rights of animals, and the…
350 | J. Eric Oliver on the Self and How to Know It
Ep 350 · Apr 13, 2026 · 1 hr 21 min
We are more familiar with ourselves than with anything else in the universe, but we generally don't come very close to really understanding what our "self" is. That's not too surprising, as selves are very complicated and we are burdened by all sorts of biases. Today's guest is J. Eric Oliver, who has been teaching a popular course at the University of Chicago called "The Intelligible Self." His academic specialty is political science, but he brings together ideas from psychology, neuroscience,…
AMA | April 2026
Apr 5, 2026 · 3 hr 47 min
Welcome to the April 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy! Henson Shaving is offering 100 blades free with…
349 | Daniel Harlow on What Quantum Gravity Teaches Us About Quantum Mechanics
Ep 349 · Mar 30, 2026 · 1 hr 26 min
There is something special about gravity. After decades of effort, there is still no convergence on the right way to reconcile Einstein's theory of general relativity with the framework of quantum mechanics. But a number of intriguing ideas have arisen along the way, including black hole radiation, the wave function of the universe, the AdS/CFT correspondence, and the role of quantum information theory. Theoretical physicist Daniel Harlow has made significant contributions to our understanding o…
348 | Jessica Riskin on Jean-Baptiste Lamarck and Life as Creative Agency
Ep 348 · Mar 23, 2026 · 1 hr 15 min
"Lamarkism" is a term often attached to a seemingly discredited idea in evolutionary biology: that one organism could acquire characteristics (e.g., becoming stronger through exercise) that would then be inherited by its descendants. This is a different story than the one ultimately told by the modern synthesis of evolutionary biology, according to which inheritance passes through our genome (which doesn't know that we've been working out). In her book The Power of Life: The Invention of Biology…
347 | Andrew Guthrie Ferguson on How Your Data Will Be Used Against You
Ep 347 · Mar 16, 2026 · 1 hr 9 min
In the 18th century, philosopher Jeremy Bentham suggested the Panopticon as a model of a prison where inmates could be constantly observed by just a single prison guard. Although his original idea was never built, the word has come to indicate any system of social control through constant surveillance. Nowadays, we are close to creating such a system, not for prisons, but for our everyday lives. The data about our whereabouts and doings is collected by our smart devices, and available for search…
346 | Erica Cartmill on How Human and Animal Minds Think and Play
Ep 346 · Mar 9, 2026 · 1 hr 28 min
Intelligence is a many splendored thing, especially when it comes to comparisons between species. Chimpanzees are better than humans at some numerical tasks, but less good at understanding what numbers actually mean. One window on the ways that species differ is how they play amongst themselves. I talk with anthropologist and cognitive scientist Erica Cartmill about modes of play and other social behaviors among various species, and what they reveal about the ways we all think. Upgrade your deni…
AMA | March 2026
Mar 2, 2026 · 3 hr 53 min
Welcome to the March 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy! Get twenty percent off your first purchase at F…
345 | Adam Elga on Being Rational in a Very Large Universe
Ep 345 · Feb 23, 2026 · 1 hr 35 min
Behaving rationally involves facing up to conditions of uncertainty; we never navigate the world with perfect confidence. Sometimes we are uncertain about the way the world is, but we can also be uncertain about our place within the world. This kind of situation arises in cosmology (where the relevant world can extend very far in space or time), and also in quantum mechanics (where new worlds might be created at any measurement), but also when we are simply unsure about the future history of hum…
344 | Adam Gurri on Liberal Democracy and How to Fight For It
Ep 344 · Feb 16, 2026 · 1 hr 21 min
It's possible to look at the course of history over the past few centuries and discern a movement toward increasing democracy, freedom, and individual rights -- "liberalism," in the political-philosophy sense of the term. But such movement isn't inevitable or irreversible, and in very recent times there have been both intellectual arguments explicitly pushing back against the liberal consensus, and political movements that are more openly nativist and authoritarian. I talk with Adam Gurri, the e…
343 | Tom Griffiths on The Laws of Thought
Ep 343 · Feb 9, 2026 · 1 hr 19 min
For all that human beings spend a lot of their time thinking, it's far from obvious what that process actually entails. Part of it amounts to classical logical reasoning. But an even bigger part involves reasoning with probability and uncertainty. And some of it is governed by unavoidable limitations on time and accuracy. Psychologist and computer scientist Tom Griffiths suggests that we have thought about it enough to feel that we have come to understand some general principles, which he explai…
AMA | Feb 2026
Feb 2, 2026 · 3 hr 10 min
Welcome to the February 2026 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy! Blog post with AMA questions and transcript:…
342 | Rachell Powell on Evolutionary Convergence, Morality, and Mind
Ep 342 · Jan 26, 2026 · 1 hr 37 min
Evolution with natural selection involves an intricate mix of the random and the driven. Mutations are essentially random, while selection pressures work to prefer certain outcomes over others. There is tremendous divergence of species over time, but also repeated convergence to forms and mechanisms that are unmistakably useful. We see this clearly in eyes and fins, but the basic pattern also holds for brains and forms of social organization. I talk with philosopher Rachell Powell about what the…
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