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Every episode
This Podcast Will Kill You
30 episodes
Special Episode: Deborah Cohen & Bad Influence
Aug 11, 2026 · 52 min
If you have a medical question, where do you turn? How often is google or social media your first stop? As you sift through the AI overview and countless reels professing to have the answers, it becomes harder and harder to separate fact from fiction. Do these supplements actually do what they promise? Should I be wary of this commonly prescribed medication? Even if you’re not directly seeking this information, it finds you anyway, preying on health anxieties and promising an easy fix. In…
Ep 218 The Lowdown on Statins
Aug 4, 2026 · 1 hr 10 min
Last week, we set the stage by breaking down the science behind cholesterol: how it moves through our body, why it causes disease, and when we discovered the link between LDL and atherosclerosis. This week, armed with that knowledge, we’re asking the big question: what do we do about high cholesterol? Statins emerged as a highly effective intervention but one that is not without its share of controversy and misinformation. We delve into the story and science of statins and other cholestero…
Ep 217 The High Stakes of Cholesterol
Jul 28, 2026 · 1 hr 4 min
So your latest blood test results have come in, and you see a couple of numbers for cholesterol. What do those numbers mean, and why do we care about them? In this first part of our cholesterol miniseries, we break down the science behind this compound and trace how we made the link between certain types of cholesterol and heart disease. First, we follow the path that cholesterol takes in our bodies and what LDL and HDL mean in the context of heart disease. Then we delve into the history of this…
Ep 216 Cyclospora: Explosive Diarrhea Everywhere
Jul 21, 2026 · 55 min
You’ve seen the headlines: a food-borne parasite is infecting people across the US, leaving them chained to the toilet sometimes for weeks on end, as they are ravaged by wave after wave of gastrointestinal upset. What the heck is cyclosporiasis and where did it come from? How scared should we be of our raspberries or lettuce or cilantro? To dish out the answers as fast we could, we put together this fact-filled episode about the biology of Cyclospora cayetanensis, how this parasite makes y…
Special Episode: Alev Scott & Cash Cow
Jul 14, 2026 · 49 min
Social media ads for egg freezing. A craigslist-like site for breast milk. Fertility fairs featuring IVF clinics alongside shamanic nutritionists. Surrogacy contracts offering a discount for multiple embryos. The rapidly-growing global fertility industry promises hope, fulfillment, and control, as long as you can afford it. Participating in this industry can be empowering. All parts of reproduction are commodified these days, so why not use your free will to take advantage of that, whether throu…
Ep 215 The Hidden Depths of Earwax
Jul 7, 2026 · 54 min
In keeping with last week’s theme of “bodily excretions that are kinda gross that you don’t really think about but are actually really important”, we’re devoting this episode to earwax, aka cerumen. In one hour, we somehow manage to weave together stories of earwax impaction, misadventures in ear candling, glimpses of earwax in art history, and a whale of a tale as revealed by cetacean cerumen. The biology and history of earwax proves to be surprisingly rich and rev…
Ep 214 Boogers: Digging for treasure
Jun 30, 2026 · 1 hr 2 min
Hard and crusty. Green and gloopy. Clear and watery. Boogers come in a veritable rainbow of colors and a full spectrum of textures from liquid to solid. They’re really quite impressive if you think about it. Which, of course, few of us do, besides adding tissues to our shopping list or cursing the dagger-like boogers that emerge during a trip to a particularly dry locale. But boogers deserve a lot more credit, and this episode is our attempt at righting that wrong. What are boogers, and wh…
Special Episode: Dr. Carl Elliott & The Occasional Human Sacrifice
Jun 23, 2026 · 58 min
Stories of unethical medical experimentation often center around the individuals who spearheaded such atrocities or highlight how patient protection laws were changed in response to the studies. But rarely do they focus on the people who fought to bring these harms to light: the whistleblower. What does it take to blow the whistle, and what does it cost? Are we all capable of blowing the whistle or is there a “whistleblower type”? What happens when there’s no one left to hear t…
Ep 213 Burns Part 2: It’s like sci-fi but real
Jun 16, 2026 · 59 min
At the turn of the 20th century, a severe burn was often a death sentence. Today, that is no longer the case. Over the past eighty years, burn care has undergone a profound transformation thanks to crucial advances across diverse areas of medicine, such as skin grafting, antiseptic technique, and fluid balance. In this episode, we trace how those pieces of the puzzle were integrated to bring new hope to those with severe burn injuries. But this revolution in burn care is far from over. As we dis…
Ep 212 Burns Part 1: The first million or so years
Jun 9, 2026 · 56 min
Burns have been a part of the human experience since our hominin relatives began controlling fire 1.5 million years ago. Until very recently, we’ve been limited in our ability to manage burn wounds with any success, having instead to rely on our body’s innate healing responses. In this episode, we delve into those repair responses, explore what makes burns different from other types of injuries, and examine how we categorize burns based on severity. On the history side of things, we…
Special Episode: Alexandra Sifferlin & The Elusive Body
Jun 2, 2026 · 51 min
An accurate diagnosis can give us so much. It can give us a path forward. It can give us answers to long-standing questions. And it can give us much-needed hope. Yet many people around the world wait years to receive an accurate diagnosis, which can take a profound physical and emotional toll. What underlies these missed or incorrect diagnoses, and what can we do about it? In this week’s TPWKY book club episode, health journalist Alexandra Sifferlin joins me to discuss The Elusive Bod…
Ep 211 Motion Sickness: It comes in waves
May 26, 2026 · 1 hr 17 min
It comes on sneakily. You become aware of your stomach. You break out in a cold sweat. Your mouth fills with saliva. And before you know it, you’re leaning over the side of the boat (or out of the car, or into the airplane sick bag), barfing up your breakfast. Motion sickness. We’ve all been there, or at least most of us have. Why? What is it about our physiology that breaks down as soon as we travel via water, vehicle, or air? That’s exactly what we’re going to explore i…
Ep 210 Histoplasmosis: Bats, birds, and budding yeast
May 19, 2026 · 1 hr 19 min
Once thought to be a rare, always fatal disease, histoplasmosis is now recognized as one of the most prevalent fungal infections in North America. It infects hundreds of thousands of people every year, and its distribution is growing. In this episode, we dissect this abundant fungus, examining how it makes us sick, who tends to get sick, and what we can do about it. We also take you through the history of this fungus, a story that features a surprise discovery, more evidence that everything is t…
Special Episode: Dr. Olivia Weisser & The Dreaded Pox
May 12, 2026 · 51 min
In a time when smallpox, tuberculosis, measles, and typhus ran rampant through the streets of London, there was another disease that instilled even more fear than these other killers: syphilis. So feared and so stigmatized was syphilis that it was sometimes called “the secret disease.” A diagnosis would not only sentence you to a drawn-out and painful illness possibly resulting in death, it also labeled you as an outcast and not fit for polite company. Skyrocketing infection rates dr…
Ep 209 Dietary Guidelines Part 2: Why is there protein in everything?
May 5, 2026 · 59 min
If you’ve come across the latest dietary guidelines, a few things may have caught your attention: a big ol’ steak front and center in the new “inverted pyramid”, beef tallow and butter recommended as “healthy” fats, a declaration that the war on protein is ending. “Since when have we been at war with protein?” you may reasonably ask. In part 2 of our episodes on dietary guidelines, we get to the bottom of the latest iteration of these guidelines an…
Ep 208 Dietary Guidelines Part 1: Who’s behind these guidelines?
Apr 28, 2026 · 58 min
Over the decades, dietary guidelines have taken a diverse array of shapes, from pamphlets to wheels, from plates to pyramids. In many cases, the shapes have changed more than the recommendations they contain. This week and next, we explore those recommendations - who’s making them, how they have changed over time, and how closely they align with what we should be eating. First, we delve into the long history of dietary guidelines and how their intentions have evolved as the food landscape…
Special Episode: Adam Kucharski & Proof
Apr 21, 2026 · 50 min
Why do we believe what we believe? Is what we believe the truth? How can we convince others of our beliefs? If you’ve ever found yourself pondering these questions, you know that the answers are rarely clear-cut. We need to form beliefs in order to navigate the world, but how skilled are we at evaluating evidence for those beliefs or weighing new data that contradicts them? In this week’s TPWKY book club episode, Adam Kucharski, Professor at the London School of Hygiene and Tropical…
Ep 207 Tear Gas: How can a chemical weapon be “humane”?
Apr 14, 2026 · 1 hr 15 min
Tear gas is an expected, normalized part of protests today. But its use in international war is banned. How can that be? That’s just one of the questions we investigate in this episode. First, we take you through the long history of tear gas and its emergence alongside deadlier chemical weapons before discussing how its use became routine, fueled by industry interests. Then we delve into what’s in tear gas that causes the painful physical reaction and consider whether claims of non-t…
Ep 206 Oropouche Virus: More than a smidge worrisome
Apr 7, 2026 · 1 hr 13 min
Though discovered relatively recently, Oropouche virus has been making headlines as an emerging vector-borne infectious disease on the rise. Not transmitted by the usual suspects (like ticks and mosquitoes), this virus is instead spread through the bites of midges or no-see-ums. Since these arthropods are already widely distributed and their range is growing thanks to climate change, this is a recipe for potential disaster. In this episode, we take you through the story of Oropouche virus, from…
Ep 205 Cancer Part 4: Where do things stand today?
Mar 31, 2026 · 1 hr 19 min
For the entirety of our species’ history, our approach to cancer has largely been to react, to design new therapies and better combinations of treatments. This energy has certainly been well-spent, but what if we didn’t have to use treatment at all? Or what if we could minimize the use of aggressive therapies? Prevention and screening represent two under-appreciated pillars of cancer care, and we’re using this final installment in our cancer miniseries to show some appreciation…
Ep 204 Cancer Part 3: How do we treat it?
Mar 24, 2026 · 1 hr 33 min
A century and a half ago, the list of effective cancer treatments was essentially a single entry: surgery. Today, in 2026, you’d need pages to contain the number of treatments available, and multiple notebooks to delineate all of the various therapies currently in development. It is nothing short of a revolution. Of course, no revolution is perfect, and many cancer treatments are ineffective or carry risks of serious side effects. In part 3 of our cancer series, we delve into all facets of…
Special Episode: Lawrence Ingrassia & A Fatal Inheritance
Mar 17, 2026 · 46 min
For centuries, physicians noticed that cancer sometimes ran in families, but until the 1960s, an answer to this mystery remained out of reach. Only then were scientists beginning to unlock the cellular dynamics underlying cancer, and what they found finally allowed grief-stricken families to put a name and explanation to their experience. It wasn’t simply bad luck. It was genetics: a heritable mutation in a key tumor suppressor gene that greatly increases the risk of developing cancer in y…
Ep 203 Cancer Part 2: Why does it happen?
Mar 10, 2026 · 1 hr 19 min
Each of our cells can become cancerous. It’s an uncomfortable, yet unavoidable truth. Nor is it a truth restricted to our species - cancer is a consequence of complex life. The features that make a cell cancerous are those that, under other circumstances, are beneficial, essential even, for an individual’s growth and survival. How is that possible? In the second installment in our series, we’re putting cancer under the microscope to consider the qualities that underlie a cancer…
Ep 202 Cancer Part 1: What is it?
Mar 3, 2026 · 1 hr 36 min
Cancer has touched every one of us in some capacity, and learning of a diagnosis inspires many more questions than it answers. In this four-part series on cancer, we aim to lay a foundation of knowledge that will help make sense of this multifaceted disease. We begin our four-part series on cancer by asking a deceptively simple question: what is cancer? As we’ll discover over the course of these episodes, there is not one answer but many. After all, cancer is not one disease but many. In t…
Special Episode: Jon Adams and Edmund Ramsden & Rat City
Feb 24, 2026 · 56 min
What happens if you put a bunch of rats in an enclosure and provision them with unlimited food and water? Researcher John B. Calhoun was committed to finding out. Results from Calhoun’s “rat utopia” experiments from the mid-20th century revealed a behavioral dark side that emerged as space grew increasingly limited, ultimately leading to complete population collapse. As headlines conveyed dire warnings about global overpopulation, Calhoun’s work served to reinforce those…
Ep 201 Poop Part 2: Flushed away
Feb 17, 2026 · 1 hr 22 min
Poop is an incredibly valuable and massively underutilized resource. However, most of us don’t see it that way because of our evolutionarily ingrained disgust towards poop. Flush toilets and intricate sewer systems have revolutionized health and hygiene by whisking our poop far away where we don’t have to think about it. But that poop has gotta go somewhere, and eventually, not thinking about it isn’t going to be an option. Similarly, not thinking about our individual poop is a…
Ep 200 Poop Part 1: How the sausage gets made
Feb 10, 2026 · 1 hr 12 min
It might be stinky and it might be unpleasant to behold, but we all do it. For many of us, our poop is out of sight, out of mind once we flush it away. But for the next hour and fifteen minutes or so, we’re going to bring it back into mind as we delve into the rich world of poop. This episode, the first of a two-part miniseries on poop, features a wide cast of characters all with some role in the production or management of poo, like our intestinal tract with its sphincters and microbiota,…
Special Episode: Nicola Twilley & Frostbite
Feb 3, 2026 · 1 hr
For much of the world, refrigeration is such a commonplace technology that we rarely stop to wonder at the many ways it has transformed our lives. From the foods we grow to where we grow them, from how they taste to what we eat, refrigeration has dramatically - and quite recently - changed our relationship to food, our health, and the environment. As Nicola Twilley describes in Frostbite: How Refrigeration Changed our Food, Our Planet, and Ourselves, progress, as it so often does,…
Ep 199 Sleep Part 2: Predictably unpredictable
Jan 27, 2026 · 1 hr 11 min
Now that we know just how critical sleep is, we’re all making sure we get the amount we need, right? Unfortunately no. One-third to one-half of Americans are not getting enough sleep, according to public health guidelines. Why is that? Hypotheses abound, but many point the finger of blame at different aspects of modern society such as screen time, artificial light, a sedentary lifestyle. These narratives suggest that sleep in industrialized societies today is not just different but worse t…
Ep 198 Sleep Part 1: Sleeping with one eye open
Jan 20, 2026 · 1 hr 14 min
Sleep is a universal experience. It’s not just the lion that sleeps tonight - it’s also the butterfly, the chicken, the jellyfish, the dog, the snake, the worm, and of course the human. What is this widespread physiological process whose spell we are all under? What purpose (or purposes) does it serve? Why do we sleep the way we do? These are just some of the questions we’re going to get into in this week’s episode, the first half of our two-parter on sleep. We break down…
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