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The a16z Show
30 episodes
How Do You Defend Against AI That Can Hack?
Ep 1172 · Aug 18, 2026 · 22 min
a16z's Joel De La Garza is joined by Nick Warner of Neo and Max Pollard of Cotool to discuss what happens when cybersecurity tools built to defend against humans and malware suddenly have to contend with AI agents. As frontier models become more capable of finding and exploiting vulnerabilities, many of the assumptions underlying traditional security are beginning to break. They explore why guardrails designed to stop AI-powered attackers can also prevent security teams from doing their jobs, wh…
Stripe’s AI Strategy: Build More, Not Less
Ep 1171 · Aug 17, 2026 · 55 min
a16z General Partner David George is joined by Will Gaybrick, President of Product & Business at Stripe, to discuss how AI is changing the way Stripe builds products, organizes teams, and thinks about the future of internet commerce. Stripe has evolved from a payments company into a multi-product financial infrastructure platform, while a new generation of AI companies is growing and monetizing faster than previous software cohorts. Will explains why Stripe sees AI productivity as an opportunity…
Ben Horowitz and Travis Kalanick on Building Again
Ep 1162 · Aug 14, 2026 · 34 min
Ben Horowitz, Travis Kalanick, and Erik Torenberg take the stage at Atoms' launch event for a candid fireside conversation about entrepreneurship, company building, and why Kalanick believes the next industrial revolution will be powered by AI. They revisit pivotal moments from Uber's history, including the decision not to acquire Lyft, lessons from scaling one of the world's fastest-growing companies, and how Kalanick has evolved as a founder. The conversation also explores Atoms' vision for in…
The Two Ways to Sell AI: Lighthouse or Landgrab?
Ep 1170 · Aug 13, 2026 · 45 min
Elena Burger is joined by a16z's Andy McCall and Joe Schmidt to break down two very different ways AI startups can go to market: the lighthouse and the landgrab. Should founders win a handful of marquee customers whose credibility unlocks an entire industry, or move quickly across a broad market where the ROI already speaks for itself? Drawing on Joe's Lighthouse or Landgrab framework and Andy's experience building sales organizations at Samsara and Meraki, they explore how founders can determin…
Garry Tan on Taste, Agents and Founder Ambition
Ep 1169 · Aug 12, 2026 · 52 min
Anish Acharya is joined by Garry Tan, President and CEO of Y Combinator, for a conversation about how AI is rewriting the startup playbook, why founders should be more ambitious than ever, and what two decades of Silicon Valley booms, busts, and missed opportunities have taught Garry about building what's next. Garry reflects on turning down an early opportunity to join Palantir, why chasing what's "hot" is often the wrong strategy, and why the best ideas tend to begin with people pursuing stran…
The CISO Playbook for AI Agents | Datadog
Ep 1168 · Aug 11, 2026 · 23 min
a16z's Joel De La Garza is joined by Emilio Escobar, Chief Information Security Officer at Datadog, to discuss what it takes to secure a company where nearly every employee is using AI and more than 4,000 engineers are working with coding agents. Rather than trying to block new tools, Emilio explains why Datadog chose to embrace AI early and build the security infrastructure needed to use it safely. They unpack how AI changes traditional assumptions around data permissions, credentials, develope…
The Self-Improving Company | Kavak's AI Playbook
Ep 1167 · Aug 10, 2026 · 37 min
Angela Strange and Gabriel Vasquez are joined by Alejandro Maza Ayala, Chief Product & AI Officer at Kavak, to unpack how the Latin American used-car marketplace rebuilt itself around AI agents, with 96% of customer interactions and 95% of transactions now handled by agents. Alejandro explains why Kavak decided that simply giving employees AI tools wasn't enough, and instead redesigned the company's systems, teams, and customer experience around agents. They discuss why Kavak spends as much engi…
The Reality of AI-Powered Cyberattacks | Truffle Security & Socket
Ep 1166 · Aug 7, 2026 · 24 min
Joel De La Garza is joined by Dylan Ayrey, co-founder and CEO of Truffle Security, and Feross Aboukhadijeh, founder and CEO of Socket, to discuss one of the biggest shifts happening in cybersecurity: AI models are no longer just finding vulnerabilities—they're exploiting them. As frontier models become increasingly capable of hacking, software security, supply chain attacks, and cyber defense are entering a fundamentally new era. The conversation explores AI-powered hacking, software supply chai…
The Engine Powering Open-Source AI
Ep 1165 · Aug 6, 2026 · 47 min
Elena Burger and Matt Bornstein are joined by Simon Mo, co-founder and CEO of Inferact, the open-source inference engine powering many of today's most advanced AI applications. Together, they explore how open-source AI evolved from a research project into critical infrastructure, why inference has become one of the most important layers of the AI stack, and what it takes to bring frontier intelligence to developers around the world. The conversation covers vLLM's origins, the rise of open-weight…
Three Startups Reinventing Critical Infrastructure
Ep 1164 · Aug 5, 2026 · 1 hr 15 min
This week, a16z American Dynamism Films premiered three short documentaries highlighting companies tackling some of America's biggest industrial challenges: Ulysses, Mariana Materials, and Radiant. Before watching those films, we're revisiting conversations with the founders behind each company. You'll hear Will O'Brien explain why autonomous underwater robots could unlock a new era of ocean exploration and security, Turner Caldwell discuss rebuilding America's critical minerals supply chain and…
OpenAI's Joshua Achiam: Did We Already Reach AGI?
Ep 1163 · Aug 4, 2026 · 31 min
Theo Jaffee is joined by Joshua Achiam, Chief Futurist at OpenAI, for a conversation on AI cybersecurity, frontier model capabilities, and why he believes society may have already crossed the threshold into an AGI-era without fully recognizing it. They discuss AI's rapidly advancing cyber capabilities, state-sponsored hacking, model jailbreaks, recursive self-improvement, and what happens when AI systems begin discovering vulnerabilities faster than humans can patch them. Joshua also explains wh…
Ruby Thelot on Internet Culture, AI, and the Future of Taste
Ep 1161 · Aug 2, 2026 · 34 min
Sophia Dew and Sofia Puccini are joined by Ruby Thelot, designer, artist, cyberethnographer, professor at NYU, and founder of 13101401, for a wide-ranging conversation about internet culture, AI, digital communities, and how technology is reshaping the way we relate to one another. Drawing on years of research into online behavior, Ruby explains how digital cultures form, why algorithms shape more than just what we see, and what AI is changing about creativity, communication, and identity. They…
Marc Andreessen and Chris Dixon: What’s at Stake in Crypto Regulation
Ep 1160 · Aug 1, 2026 · 60 min
Marc Andreessen, Chris Dixon, and Robert Hackett discuss one of the most consequential policy debates facing the crypto industry: the push for comprehensive U.S. market structure legislation and what regulatory clarity could mean for innovation, financial markets, and America's technological leadership. They explore the CLARITY Act, stablecoins, securities law, consumer protection, and why both builders and financial institutions are calling for clear rules of the road. Along the way, they discu…
How Enterprise AI Really Gets Deployed
Ep 1159 · Jul 31, 2026 · 1 hr 21 min
Sarah Wang and Kimberly Tan are joined by Jesse Zhang and Ashwin Sreenivas, co-founders of Decagon, to discuss the evolution of enterprise AI agents, why the company increasingly relies on open-source models, and how it is helping some of the world’s largest companies deploy AI in production. Decagon has become one of the fastest-growing AI companies by building agents that automate customer support, sales, and operational workflows. Jesse, Decagon’s CEO, and Ashwin, its president, explain how t…
AI for America's Small Businesses | Lassie
Ep 1158 · Jul 30, 2026 · 59 min
Alex Rampell and Olivia Moore speak with Lassie cofounders Steijn Pelle and Frédéric Renken about bringing AI to one of the most overlooked parts of the economy: small businesses. Inspired by time spent working inside dental practices, Pelle and Renken set out to automate the administrative work that keeps healthcare providers away from patients. They discuss how AI agents are changing billing, insurance claims, patient payments, and other operational workflows, allowing practices to spend less…
AI Micro Dramas, Generative Media, and the Future of Creativity
Ep 1157 · Jul 29, 2026 · 51 min
Justine Moore, partner at Andreessen Horowitz, joins New Economies to explore the rapid evolution of generative media and why AI-native content is reaching an inflection point. They discuss the rise of AI micro-dramas, how creators are building entirely new forms of entertainment, and why the biggest opportunities may lie not in replacing Hollywood—but in expanding who gets to create. They also cover the future of creator tools, AI agents for individuals, generative video, AI "slop," the economi…
Fei-Fei Li on Spatial Intelligence and Robotics
Ep 1156 · Jul 28, 2026 · 43 min
Last week, World Labs announced its acquisition of SceniX, bringing together two teams working on one of AI's biggest unsolved problems: how to give machines a true understanding of the physical world. Martin Casado sits down with Fei-Fei Li, co-founder and CEO of World Labs, creator of ImageNet, and pioneer of spatial intelligence, alongside Yunzhu Li, co-founder of SceniX and assistant professor at Columbia University. They discuss why World Labs acquired SceniX, how simulation can unlock the…
Steven Sinofsky: AI Doesn't Need New Rules Yet
Ep 1155 · Jul 27, 2026 · 29 min
Steven Sinofsky joins Theo Jaffee and Sofia Puccini for a conversation on AI regulation, open-source models, and what history can teach us about technological revolutions. Drawing on decades of experience leading products at Microsoft, Sinofsky argues that governments are rushing to regulate AI before they fully understand the technology, risking innovation in the process. They discuss the "precautionary principle," why open source has historically accelerated innovation, the role of regulation…
Ben Horowitz: The Fight Over Open Source AI
Ep 1154 · Jul 26, 2026 · 33 min
Ben Horowitz joins Theo Jaffee and Sofia Puccini to discuss one of the biggest debates in AI today: the future of open-source models. They examine the growing push to restrict open models, why Ben believes open source is critical for security, innovation, and competition, and what happens if a handful of frontier labs come to dominate the AI ecosystem. They also discuss distillation, AI monopolies, China's role in open-source AI, robotics, manufacturing, the economics of frontier models, and why…
Sriram Krishnan on Open Source AI's Biggest Week Yet
Ep 1153 · Jul 24, 2026 · 23 min
Sriram Krishnan joins Theo Jaffee and Sofia Puccini just after concluding his tenure as Senior White House Policy Advisor on AI to discuss one of the biggest weeks yet for open-source AI. They unpack the rapid release of models including Kimi K3 and Qwen, why open models are putting pressure on frontier labs, and what it means for pricing, competition, and the future of AI infrastructure. They also discuss AI policy, distillation, cybersecurity, the role of open-weight models, whether the U.S. s…
Building the Physical AI Stack | Travis Kalanick on TBPN
Ep 1152 · Jul 23, 2026 · 45 min
Travis Kalanick joins TBPN to discuss Atoms, his vision for industrial AI, and why he believes the biggest opportunities in AI lie beyond software. He explains how Atoms is bringing autonomy to mining, logistics, and food production, why robotics will reshape physical industries, and how lower costs and greater automation could unlock entirely new economic opportunities. Travis also reflects on raising $1.7 billion, building in stealth, regulation, hiring, and what he's learned since Uber. Resou…
Travis Kalanick Is Back | Building the Future of Industrial AI
Ep 1151 · Jul 22, 2026 · 1 hr 32 min
Travis Kalanick, Ben Horowitz, and Erik Torenberg reunite to reflect on Uber's early days, the investment that almost happened, and why Kalanick believes the next great technology opportunity lies beyond software. They discuss the lessons of building Uber, the value of founder-led companies, and why Kalanick spent nearly eight years quietly building Atoms before stepping back into the spotlight. The conversation explores industrial AI, robotics, autonomy, mining, food production, and Kalanick's…
Why Physical AI Is the Next Frontier | Applied Intuition
Ep 1150 · Jul 21, 2026 · 1 hr 21 min
Applied Intuition has spent the past decade building the software that powers intelligent machines, from passenger vehicles and trucks to defense systems, mining equipment, and industrial robots. In this conversation, Marc Andreessen and Erik Torenberg sit down with Applied Intuition cofounders Qasar Younis and Peter Ludwig to discuss the emergence of physical AI and the company's latest launch, Dana, a new platform designed to accelerate the development of autonomous systems. They explore auton…
Hugging Face's CEO on Open Source AI, Model Routing, and the Future of Competition
Ep 1149 · Jul 20, 2026 · 28 min
As governments weigh new restrictions on frontier AI models, one question is becoming increasingly important: what role should open source play in the future of artificial intelligence? Theo Jaffee and Sofia Puccini speak with Hugging Face CEO Clément Delangue about AI regulation, open source safety, model routing, and why he believes competition—not consolidation—is essential for the industry's future. They discuss GPT-5, government oversight of frontier models, Hugging Face surpassing $100 mil…
Amjad Masad on Going Direct, Building Replit, and the Future of Software
Ep 1148 · Jul 17, 2026 · 26 min
Recorded live at the New Media Summit, Erik Torenberg sits down with Replit founder and CEO Amjad Masad to discuss founder-led storytelling, building in public, and the role of media in company building. Masad reflects on Replit’s decade-long journey, including the years before the company’s recent breakout growth, and explains why communicating a vision can be just as important as executing on it. He argues that for many founders, especially those building ambitious products ahead of the market…
Replay 2025: David Sacks on AI, Crypto, and America's Technology Future
Ep 1147 · Jul 16, 2026 · 1 hr 17 min
As part of our summer replay series, we're revisiting one of our most-discussed conversations from the past year. David Sacks joins Marc Andreessen, Ben Horowitz, and Erik Torenberg to discuss the intersection of AI, crypto, regulation, and American competitiveness. The conversation explores the Trump administration's approach to AI and crypto policy, open source AI, export controls, energy and infrastructure, the global race with China, and the role regulation plays in shaping innovation. They…
From the Archive: Can Anyone Catch NVIDIA? | The Future of Chips and Infrastructure
Ep 1146 · Jul 15, 2026 · 1 hr 5 min
As part of our summer replay series, we're revisiting one of our favorite conversations on the future of AI infrastructure. SemiAnalysis founder Dylan Patel joins Erin Price-Wright, Guido Appenzeller, and Erik Torenberg to examine the rapidly evolving economics of AI hardware, from GPUs and custom silicon to data centers, power, and the global race for compute. The conversation explores NVIDIA's competitive advantages, the rise of custom chips from Google, Amazon, and Meta, the economics of fron…
Is AI a Bubble? | Gavin Baker on Data Centers, GPUs, and the AI Economy
Ep 1145 · Jul 14, 2026 · 32 min
As part of our summer replay series, we're revisiting one of the standout conversations from Runtime, a16z's conference on AI infrastructure and the future of computing. Gavin Baker, Managing Partner and CIO of Atreides Management, joins David George to examine the biggest questions surrounding today's AI investment cycle. Is AI a bubble? What does the unprecedented buildout of data centers, GPUs, and compute infrastructure mean for the economy? And how should investors think about the companies…
Before Blockchains, There Was State Machine Replication
Ep 1144 · Jul 13, 2026 · 37 min
Every blockchain today relies on replication techniques first developed in the 1980s by researchers who weren't thinking about cryptocurrencies at all. In this episode, Tim Roughgarden speaks with MIT professor and Turing Award winner Barbara Liskov, one of the pioneers of programming languages, fault tolerance, and distributed systems. Joined by a16z crypto research partner Ittai Abraham, they trace the evolution of ideas that now underpin modern blockchain networks. The conversation explores v…
How Bitcoin Rewired a Classic Computer Science Problem
Ep 1143 · Jul 10, 2026 · 22 min
We're excited to share a special feed drop from The a16z Crypto Show. In the first episode of First Principles: The Scientific Roots of Blockchain Technology, Tim Roughgarden and Ittai Abraham trace the decades of computer science research that laid the foundation for modern blockchains. Long before Bitcoin, researchers were studying one of distributed computing's hardest challenges: how independent machines can reliably agree on a shared state, even when some participants are faulty or maliciou…
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