Raphael strives to capture the open and sympathetic face of his friend and deliberately simplifies his composition. Yet the image is filled with clues and can be interpreted today using both traditional laboratory analysis and historical archives. The technical details of the pictorial surface, the choice of colors, and the hidden symmetries of the image already reveal how the painting was created. But the clothing, the hairstyle, the materials used, and even the model’s gaze—or the way the reflections are placed in his eyes—each carry a precise meaning within this composition.