A balanced and straightforward survey of the key issues, facts, and controversies surrounding the use and abuse of harmful drugs in the United States and abroad. Drug Use: A Reference Handbook presents a vast collection of facts and information about the major issues that drive the world's never-ending drug problem. An examination of five substances―tobacco, alcohol, cannabis, heroin, and cocaine―presents eye-opening facts about their relationship to politics, policies, big business, and war. Historical overviews and descriptions of the makeup and effects of each drug―such as the derivation of heroin from the opium poppy―segue into an analysis of the risk factors, patterns, and controversies regarding their use. Biographies profile key players related to the substance-use problem, and reports on drug use in the United States and selected countries are viewed from a worldwide perspective, offering a thought-provoking exploration of drug use, its problems, and policies.