The leading annually updated, comprehensive and reliable general medical reference available to answer common questions in everyday clinical practice. New Informatics in Patient Internet, E-mail Telemedicine, and Clinical Decision Support - provides guidance on using new and estabished technologies as effective aids in the medical setting; new section on fragile X mental retardaton; new developments in diagnosis and treatment of ischemic heart disease and pulmonary embolism; updated information on drug dosing and costs, therapeutic options in HIV, apporaches to multi-drug antiretroviral therapy and so much more!