The book describes in detail the genetics, neurobiology, pathophysiology, and experimental modelling of multiple sclerosis. Though written to be read as a whole, each chapter can also be read separately. The text is written in a highly readable style, andis extensively illustrated in colour. This new classic work on Multiple Sclerosis charts the progress that has been and is being made in understanding this difficult disease. This book has its origins in the work written by Douglas McAlpine, Nigel Compston, and Charles Lumsden in 1955 but not one word survives from that edition or the previous edition of McAlpines Multiple Sclerosis published in 1992. This edition describes in more detail than before the genetics, neurobiology, pathophysiology, and experimental modelling of multiple sclerosis. The emphasis is always on clinical, epidemiological and therapeutic aspects of the disease. Each chapter is well illustrated, including a full colour section. new edition of the classic book on the subject four new authors, all internationally known authorities from UK, Canada, Germany & Austria much more on imaging and investigations than 2E new chapter on neurobiology and glial development much better illustrated than 2E very well referenced totally rewritten, except for chapters 2 & 3 on symptoms and diagnosis, which have been revised