Spider-Man's most mysterious new enemy takes center stage in this story by Official Amazing Spider-Man Web-Head Fred Van Lente and newcomer Gianluca Gigliotta. One-half benevolent philanthropist/One-half underworld mastermind, Mr. Negative has carved out a substantial slice of the big apple for himself over the past year. But when the super-villain mastermind The Hood strikes at the heart of Mr. Negative's criminal operations with a whole horde of classic Arachno-Foes (including The Scorcher, Speed Demon, The Squid, and the long-awaited return of the White Rabbit), Spider-Man is left to clean up the mess between these two violent nemeses. Collects Dark Reign: Mister Negative #1-3.