To clinical microbiologists, laboratory technologists, and infectious disease specialists for 40 years, enabling them to accurately detect clinically significant bacteria, viruses, fungi, and parasites. This 10th edition represents the collaborative efforts of 22 editors and more than 260 authors from around the world, all experienced researchers and practitioners in medical and diagnostic microbiology. Together, they have brought the manual fully up to date, producing two volumes, nine sections, and 149 chapters that is filled with the latest research findings, infectious agents, methods, practices, and safety guidelines. This 10th edition continues to set the standard for state-of-the-science laboratory practice. It begins with a section dedicated to core diagnostic strategies and topics. Next, it helps readers understand the underlying mechanisms of both common and emerging infectious agents and diseases. With its careful step-by-step guidance, the Manual enables readers to correctly perform the appropriate diagnostic, therapeutic, and susceptibility tests and then interpret the results. Rounding out its coverage, the Manual addresses the taxonomy, biology, epidemiology, transmission, and clinical significance of almost all microorganisms that cause disease in humans. Fully updated and revised, this edition encapsulates the knowledge, practices, and procedures of the field, enabling readers to accurately detect pathogens and diagnose infectious disease.