These articles deal with the functioning, and malfunctioning, of the Carreira da India, the round voyages made between Portugal and its possessions in India that began after Vasco da Gama had opened up the route round the Cape of Good Hope in 1497-99. On such voyages was the Portuguese colonial empire built, and these studies illustrate the conditions under which they operated - the ships, the crews, their navigation and their cargoes. For instance, details are given of the medicines carried on board and the hospital established at the way-station of Moçambique in an attempt to combat the perennial scourge of disease.