This book constitutes the thoroughly refereed post-workshop proceedings of two workshops held at the International Conference on Artificial Intelligence in Medicine, AIME 2015, held in Pavia, Italy, in June 2015: the 7th International Workshop on Knowledge Representation for Health Care, KR4HC 2015, and the 8th International Workshop on Process-oriented Information Systems in Healthcare, ProHealth 2015. The 10 revised full papers were carefully reviewed and selected from 26 submissions. The papers are organized in topical sections on knowledge-driven health IT and simulation, clinical guideline and clinical pathway support, mobile process and decision support, and health information systems and clinical data.